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Human CHRM3-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0318
Background
The muscarinic M3 receptor is a 590-amino acid, 7-transmembrane protein. RT-PCR and radioligand binding assays detected M3 expression in the bladder, gastric and intestinal smooth muscle, brain (CNS) and the vestibular system. Muscarinic M3 receptors mediate contraction of airway and bladder smooth muscles. The receptors in the urothelium/suburothelium can also modulate the release of certain factors, which in turn may affect bladder function at the efferent or afferent axis. Blockade of M3 receptors can alleviate the symptoms of OAB. M3 receptors are also expressed myocardial tissues and are of potential roles in parasympathetic control of heart function under normal physiological conditions and in heart failure, myocardial ischemia and arrhythmias.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CHRM3
Synonyms
CHRM3; cholinergic receptor, muscarinic 3; muscarinic acetylcholine receptor M3; acetylcholine receptor; muscarinic 3; m3 muscarinic receptor; acetylcholine receptor, muscarinic 3; HM3; EGBRS;
Gene ID
MIM
UniProt ID
P20309
Chromosome Location
1q41-q44
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; acetylcholine binding; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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