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Human CHRM2-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0317
Background
The muscarinic M2 receptor is a 466-amino acid, 7-transmembrane protein. In heart muscle, M2 receptors represent the prevailing subtype of muscarinic receptors. They can also be found in neurons of central and peripheral nervous system. In neuronal cells, mainly on synaptic terminals, stimulation of the M2 autoreceptors is responsible for presynaptic muscarinic autoinhibition of acetylcholine release in both central and peripheral cholinergic neurons. Loss of function of these M2 receptors, as occurs in some patients with asthma and in animal models of inflammation, leads to an increase in vagally mediated hyperreactivity.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CHRM2
Synonyms
CHRM2; cholinergic receptor, muscarinic 2; muscarinic acetylcholine receptor M2; acetylcholine receptor; muscarinic 2; 7TM receptor; muscarinic M2 receptor; acetylcholine receptor, muscarinic 2; cholinergic receptor, muscarinic 2, isoform a; HM2; FLJ43243; MGC120006; MGC120007;
Gene ID
MIM
UniProt ID
P08172
Chromosome Location
7q35-q36
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; drug binding; receptor activity; signal transducer activity;

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