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Human CHRM1 Stable Cell Line-CHO

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Cat.No.
CSC-RG0872
Background
Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled receptors (GPCRs). They are relatively abundant and mediate many of the diverse actions of acetylcholine in the CNS as well as throughout non-nervous tissues innervated by the parasympathetic nervous system. At present, five receptor subtypes (M1 - M5) have been identified. The odd-numbered receptors (M1, M3, and M5) are preferentially coupled to G(q/11). The even-numbered receptors (M2 and M4) are coupled to G(i/o). They also activate G protein-gated potassium channels, which leads to hyperpolarization of the plasma membrane in different excitable cells. Among the five subtypes, M1 receptor is important in excitatory postsynaptic potential in autonomic ganglia, secretion from salivary glands and stomach, memory and Alzheimers disease.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages (6 weeks of continuous culture)
Ship
Dry ice
Gene Information
Official Symbol
CHRM1
Synonyms
CHRM1; cholinergic receptor, muscarinic 1; muscarinic acetylcholine receptor M1; acetylcholine receptor; muscarinic 1; acetylcholine receptor, muscarinic 1; M1; HM1; M1R; MGC30125;
Gene ID
MIM
UniProt ID
P11229
Chromosome Location
11q12-q13
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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