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Human CHRM1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0595
Background
The muscarinic acetylcholine receptor family consists of five GPCRs that mediate some of the neurotransmission functions of acetylcholine in the CNS and the periphery. The M1 receptor, along with the M3 and M5 receptors, signal through Gq/11 and subsequent release of Ca2+ from the ER. The M1 receptor is expressed in ganglia and mediates depolarization of ganglia by inhibition of voltage-gated M-type K+ channels. In addition,the M1 receptor mediates venous contraction.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CHRM1
Synonyms
CHRM1; cholinergic receptor, muscarinic 1; muscarinic acetylcholine receptor M1; acetylcholine receptor; muscarinic 1; acetylcholine receptor, muscarinic 1; M1; HM1; M1R; MGC30125;
Gene ID
MIM
UniProt ID
P11229
Chromosome Location
11q12-q13
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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