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Human CHRM1-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0315
Background
The muscarinic M1 receptor is a membrane protein with seven transmembrane segments and binds with acetylcholine on the extracellular surface. The acetylcholine-bound receptor interacts with and activates G protein Gq/G11. The receptor is found in the hippocampal and cortical regions of the brain as well as in the parasympathetic ganglia. It is involved in many processes, including the initiation of seizures, learning and memory, and regulation of the force and rate of heart contractions. Because of its involvement in these processes, the M1 receptor is a compelling drug target for Alzheimers disease and other neurological and psychiatric disorders.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
CHRM1
Synonyms
CHRM1; cholinergic receptor, muscarinic 1; muscarinic acetylcholine receptor M1; acetylcholine receptor; muscarinic 1; acetylcholine receptor, muscarinic 1; M1; HM1; M1R; MGC30125;
Gene ID
MIM
UniProt ID
P11229
Chromosome Location
11q12-q13
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
Function
G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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