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Human CCR4/Galpha15 Stable Cell Line-Chem-5

Cat.No.
CSC-RG0631
Abbr
Chem-5-HuCCR4/Galpha15
Alias
CCR4,CC CKR 4,CD194,ChemR13,CKR4,CMKBR4,k5 5,CCR-4,C-C CKR-4,K5-5,CC-CKR-4,HGCN:14099,MGC88293
Growth Properties
Adherent
Host Cell
Chem-5
Shipping
Dry ice
Species
Human
Background
CCR4 is a GPCR that is activated by chemokines TARC (thymus and activation regulated chemokine) and MDC (macrophage-derived chemokine). NK cells, Th2 cells, cutaneous memory T cells, macrophages and platelets express CCR4 and respond to TARC and MDC. CCR4-null mice display reduced airway hyperresponsiveness to fungal spores, lipopolysaccharide-induced endotoxic shock, and cardiac allograft rejection. In addition, antibody-mediated antagonism of MDC inhibits development of insulitis and diabetes in NOD mice.

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