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Human CCR10/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0628
Background
CCR10, previously known as GPR2, is a GPCR that is expressed in dermal endothelial cells, fibroblasts, melanocytes, and circulating T cells and PBMCs. Two chemokines, CTACK/CCL27 and MEC/CCL28, bind to CCR10 and stimulate migration and calcium flux. Expression of CTACK by keratinocytes, and CCR10 by lymphocytes from skin of patients with psoriasis and dermatitis, implicates this receptor ligand pair in skin inflammation. In addition, disruption of CCL27-CCR10 interaction reduces skin inflammation induced by allergen. CCR10 expressed on IgA antibody-secreting cells also mediates their migration to CCL28 expressed in the lactating mammary gland, and subsequent IgA accumulation in milk.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CCR10
Synonyms
CCR10; chemokine (C-C motif) receptor 10; G protein coupled receptor 2 , GPR2; C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2; GPR2;
Gene ID
MIM
UniProt ID
P46092
Chromosome Location
17q21.1-q21.3
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function
C-C chemokine receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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