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Human CCR1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0627
Background
CCR1 is a GPCR that binds to a variety of CC ligands, including MIP-1, RANTES, MCP-3, HCC-1, HCC-2, HCC-4, and MPIF-1. Lymphocytes, macrophages, dendritic cells, and GM-CSF-activated neutrophils express CCR1. Two selective, non-peptide small molecule antagonists of CCR1, BX-471 and CP-481,715, have been synthesized. Pharmacological and genetic targeting of CCR1, either alone or in combination with cyclosporin A, reduces cardiac and renal allograft rejection, allergic encephalomyelitis, and renal fibrosis in experimental models.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CCR1
Synonyms
CCR1; chemokine (C-C motif) receptor 1; CMKBR1, SCYAR1; C-C chemokine receptor type 1; CD191; CKR 1; MIP1aR; CCR-1; CC-CKR-1; RANTES-R; C-C CKR-1; MIP-1alpha-R; LD78 receptor; RANTES receptor; macrophage inflammatory protein 1-alpha receptor; CKR1; CKR-1; HM145; CMKBR1; SCYAR1;
Gene ID
MIM
UniProt ID
P32246
Chromosome Location
3p21
Pathway
Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function
C-C chemokine binding; C-C chemokine receptor activity; G-protein coupled receptor activity; chemokine (C-C motif) ligand 5 binding; chemokine (C-C motif) ligand 7 binding; chemokine receptor activity; phosphatidylinositol phospholipase C activity; protein binding; receptor activity; signal transducer activity;

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