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Human CALCR+RAMP1/Gs Stable Cell Line-1321N1

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Cat.No.
CSC-RG0584
Background
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
Growth Properties
Adherent
Morphology
Glial
Host Cell
1321N1
Ship
Dry ice
Gene Information
Official Symbol
RAMP1
Synonyms
RAMP1; receptor (G protein-coupled) activity modifying protein 1; receptor (calcitonin) activity modifying protein 1 , receptor activity modifying protein 1; receptor activity-modifying protein 1; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1;
Gene ID
MIM
UniProt ID
O60894
Chromosome Location
2q36-q37.1
Pathway
Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
calcitonin receptor activity; calcitonin receptor binding; coreceptor activity; protein binding; protein transporter activity; receptor activity;

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