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Human CALCRL/Galpha15 Stable Cell Line-Chem-1

See other products for CALCRL
Cat.No.
CSC-RG0622
Background
The calcitonin family of peptides, which includes calcitonin, two calcitonin-related gene peptides (CGRPs), adrenomedullin, and amylin, share a disulfide-bonded loop, an amphipathic a-helix, and an amidated C-terminus. The peptides influence a variety of physiological effects, including vascular tone, food intake and bone metabolism. The biological effects of the peptides are mediated by two class B GPCRs, CT receptor (calcitonin receptor) and CL receptor (calcitonin receptor-like receptor). The pharmacology of the CT and CL receptors is strongly influenced by their association with a family of three receptor activity modifying proteins (RAMPs), which are 14-17 kD single pass transmembrane proteins. CGRP (calcitonin gene-related peptide) induces vasodilation, and its activity is primarily mediated by CGRP1, composed of CL in complex with RAMP1. As a consequence of its role as a vasodilator, CGRP acting via CGRP1 appears to play an important role in hypertension.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
CALCRL
Synonyms
CALCRL; calcitonin receptor-like; calcitonin gene-related peptide type 1 receptor; CGRPR; CRLR; CGRP type 1 receptor; calcitonin receptor-like receptor;
Gene ID
MIM
UniProt ID
Q16602
Chromosome Location
2q21.1-q21.3
Pathway
Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; calcitonin gene-related polypeptide receptor activity; calcitonin receptor activity; protein binding; protein transporter activity; receptor activity; signal transducer activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-SC002296
HEK293 ,CHO, etc.
CALCRL
Human
CSC-DC002296
HEK293 ,Hela, etc.
CALCRL
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD02914Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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