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Human C3AR1/beta-Arrestin Stable Cell Line-U2OS

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Cat.No.
CSC-RG1421
Background
C3a receptor (C3a anaphylatoxin chemotactic receptor) is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. The receptor is widely expressed in many hematopoietic cell lines, throughout the CNS and other tissues, and the expression level in glial cells increases during CNS inflammation. It stimulates chemotaxis, granule enzyme release and superoxide anion production, mediates the pathogenesis of demyelinating disease by directly or indirectly chemoattracting encephalitogenic cells to the CNS. Administration of small molecule inhibitors of C3a receptor inhibits airway responses.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
C3AR1
Synonyms
C3AR1; complement component 3a receptor 1; C3a anaphylatoxin chemotactic receptor; AZ3B; C3AR; C3a-R; complement component 3 receptor 1; HNFAG09;
Gene ID
MIM
UniProt ID
Q16581
Chromosome Location
12p13.31
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
C3a anaphylatoxin receptor activity; G-protein coupled receptor activity; complement component C3a binding; complement component C3a receptor activity; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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