Human C3AR1/Apoaequorin Stable Cell Line-CHO

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Cat.No.

CSC-RG1245

Background

C3a, along with C4a and C5a, is a 77 amino acid anaphylotoxin generated by proteolytic cleavage during activation of the complement pathway. The anaphylotoxins strongly promote inflammation by recruiting leukocytes, particularly basophils, eosinophils, neutrophils and monocyte. The proinflammatory properties of C3a are mediated by interaction between the peptide and a 7-TM G-protein coupled receptor, C3aR. Genetic and pharmacological inhibition of C3a/C3aR interaction indicates an important role for C3aR in allergic asthma. C3a/C3aR also enhances the effect of SDF-1 in promoting retention of haematopoietic stem/progenitor cells within the bone marrow.

Growth Properties

Adherent

Morphology

Epithelial-like

Host Cell

CHO-K1

Ship

Dry ice

Gene Information

Gene Name

C3AR1 complement component 3a receptor 1 [ Homo sapiens ]

Official Symbol

C3AR1

Synonyms

C3AR1; complement component 3a receptor 1; C3a anaphylatoxin chemotactic receptor; AZ3B; C3AR; C3a-R; complement component 3 receptor 1; HNFAG09;

Gene ID

719

MIM

605246

UniProt ID

Q16581

Chromosome Location

12p13.31

Pathway

Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;

Function

C3a anaphylatoxin receptor activity; G-protein coupled receptor activity; complement component C3a binding; complement component C3a receptor activity; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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C3AR1

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