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Human BRS3/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1252
Background
Bombesin, a bioactive peptide first identified in amphibian skin, is related to two mammalian peptides, gastrin-releasing peptide (GRP) and neuromedin B. A family of 3 GPCRs, including GRP-R (BB1), NMB-R (BB2) and BRS-3 (BB3), mediate the biological effects of the peptides. BB3 differs from the others by its low affinity for bombesin. Although an endogenous ligand for BB3 has yet to be identified, a synthetic nonselective bombesin-like peptide [D-Phe6, beta-Ala11, Phe13, Nle14]-bombesin-(6-14)-amide activates BB3 with high potency. BB3-null mice develop mild obesity that can be alleviated by treatment with an antiobesity compound, the serotonin and noradrenaline reuptake inhibitor Sibutramine.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
BRS3
Synonyms
BRS3; bombesin-like receptor 3; bombesin receptor subtype-3; BRS-3; G-protein coupled receptor; bombesin receptor subtype 3;
Gene ID
MIM
UniProt ID
P32247
Chromosome Location
Xq26.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; bombesin receptor activity; receptor activity; signal transducer activity;

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