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Human AVPR2-FLAG Stable Cell Line-CHO

Cat.No.
CSC-RG0416
Abbr
CHO-HuAVPR2-FLAG
Alias
AVPR2,DIR,DIR3,V2R,DI1,DIR,NDI,ADHR,DIR3,MGC126533,MGC138386
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Human
Background
V2, a G protein coupled receptor, also called arginine vasopressin receptor 2 (AVPR2), is a receptor for neurohypophyseal peptide [Arg8]-vasopressin. It is expressed in the kidney tubule, mainly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer. In the kidney, V2 receptor responds to vasopressin and activates mechanisms that concentrate urine and maintain water homeostasis in the body. Loss of function of the V2 receptor results in nephrogenic diabetes insipidus. The primary transduction mechanism is via adenylate cyclase stimulation to raise intracellular cAMP levels. Selective antagonists for V2 can be used to treat hyponatremia.
For research use only. Not intended for any clinical use.

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