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Human AVPR2-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0416
Background
V2, a G protein coupled receptor, also called arginine vasopressin receptor 2 (AVPR2), is a receptor for neurohypophyseal peptide [Arg8]-vasopressin. It is expressed in the kidney tubule, mainly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer. In the kidney, V2 receptor responds to vasopressin and activates mechanisms that concentrate urine and maintain water homeostasis in the body. Loss of function of the V2 receptor results in nephrogenic diabetes insipidus. The primary transduction mechanism is via adenylate cyclase stimulation to raise intracellular cAMP levels. Selective antagonists for V2 can be used to treat hyponatremia.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
AVPR2
Synonyms
AVPR2; arginine vasopressin receptor 2; DIR, DIR3; vasopressin V2 receptor; nephrogenic diabetes insipidus; V2R; AVPR V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor; DI1; DIR; NDI; ADHR; DIR3; MGC126533; MGC138386;
Gene ID
MIM
UniProt ID
P30518
Chromosome Location
Xq28
Pathway
Aquaporin-mediated transport, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; vasopressin receptor activity;

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