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Human AVPR2/Apoaequorin Stable Cell Line-CHO

Cat.No.
CSC-RG1347
Abbr
CHO-HuAVPR2/Apoaequorin
Alias
AVPR2,DIR,DIR3,V2R,DI1,DIR,NDI,ADHR,DIR3,MGC126533,MGC138386
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Human
Background
Arginine vasopressin (AVP) is a 9 amino acid peptide that functions as an antidiuretic, vasoconstrictor and neurotransmitter. The three vasopressin receptors, V1a, V1b and V2, are GPCRs; V1a and V1b couple to Gq and calcium release, whereas V2 couples to Gs. V2 expressed in renal collecting ducts plays an important role in regulating renal free water excretion. Mutations in V2 result in X-linked nephrogenic diabetes insipidus, a syndrome in which the kidney is unable to concentrate urine, leading to dehydration and hypernatremia. Conversely, elevated levels of AVP lead to hyponatremia in the syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure or cirrhosis, and V2 selective antagonists have been developed to treat these conditions.
For research use only. Not intended for any clinical use.

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