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Human AVPR1A-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0414
Background
V1A, a G protein coupled receptor, also called arginine vasopressin 1A (AVPR1A), is a receptor for neurohypophyseal peptide [Arg8]-vasopressin. V1A has shown to be highly expressed in the posterior pituitary gland, where it plays an essential role in controlling the water content of the body by acting on the kidney to increase water and sodium absorption. It is also abundant in the periphery in vascular smooth muscle, myometrium and the bladder, where it also acts to mediate contraction. Other functions include glycogen breakdown in the liver, inducing platelet activation, and triggering the release of corticotrophin from the anterior pituitary gland. Vasopressin is used clinically to treat diabetes insipidus. V1a receptor signals through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+. Studies have shown V1A receptor antagonists to selectively block aggressive behavior in hamsters. Repeat variations in V1A has also been associated with the risk of autism, level of musical cognition, and level of altruism.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
AVPR1A
Synonyms
AVPR1A; arginine vasopressin receptor 1A; AVPR1; vasopressin V1a receptor; V1aR; AVPR V1a; V1a vasopressin receptor; antidiuretic hormone receptor 1A; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; vascular/hepatic-type arginine vasopressin receptor;
Gene ID
MIM
UniProt ID
P37288
Chromosome Location
12q14-q15
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled receptor activity; V1A vasopressin receptor binding; peptide hormone binding; protein binding; protein kinase C binding; receptor activity; signal transducer activity; vasopressin receptor activity;

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