AT1 (Angiotensin II, type 1) receptor is an angiotensin receptor with vasopressor effects and regulates aldosterone secretion. It is essential in controlling blood pressure and volume in the cardiovascular system. AT1 receptor antagonists are drugs useful in the treatment of hypertension, diabetic nephropathy and congestive heart failure. Blockade of AT1 receptors could also be a novel approach in the treatment of mood disorders and neurodegenerative diseases of the brain.
G-protein coupled receptor activity; acetyltransferase activator activity; angiotensin type I receptor activity; angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity; receptor activity; signal transducer activity;