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Human ADRBK2/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0610
Background
The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central nervous system actions. These activities are mediated by GPCRs belonging to two subfamilies, the alpha- and beta-adrenergic receptors. The beta-adrenergic receptors, primarily the beta2 subtype, mediate relaxation of smooth muscle in many tissues, and beta2-selective agonists are the preferred drugs for stimulating bronchodilation in the treatment of asthma and chronic obstructive pulmonary disease. Activation of the beta-adrenergic receptors, primarily the beta1 subtype and to a lesser extent the beta2 subtype, acutely increases heart rate, cardiac output, and cardiac automaticity, and chronically increases cardiac myocyte apoptosis. As a result, beta-adrenergic receptor antagonists (beta blockers) are effective in the treatment of congestive heart failure and arrhythmia.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
ADRBK2
Synonyms
ADRBK2; adrenergic, beta, receptor kinase 2; beta-adrenergic receptor kinase 2; BARK2; GRK3; beta-ARK-2; G-protein-coupled receptor kinase 3;
Gene ID
MIM
UniProt ID
P35626
Chromosome Location
22q11
Pathway
Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; IL-4 signaling Pathway, organism-specific biosystem;
Function
ATP binding; G-protein coupled receptor kinase activity; beta-adrenergic receptor kinase activity; nucleotide binding; protein kinase activity; transferase activity, transferring phosphorus-containing groups;

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