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Human ADRB3/Galpha15 Stable Cell Line-Chem-10

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Cat.No.
CSC-RG0611
Background
The beta adrenergic receptors mediate the effects of endogenous catecholamines, such as epinephrine, by coupling to Gs to stimulate cAMP. Whereas beta1 and beta2 are found predominantly in heart, the beta3 receptor is found primarily in adipose tissue. Activation of adipose beta3 results in lipolysis and thermogenesis. A polymorphism in the human gene for beta3 is associated with weight gain in obese patients. In addition, mice lacking the beta3-adrenoceptor display increased total body fat, particularly on a high fat diet. These observations indicate that beta3 is a possible target for obesity treatments.
Growth Properties
Adherent
Host Cell
Chem-10
Ship
Dry ice
Gene Information
Official Symbol
ADRB3
Synonyms
ADRB3; adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor; BETA3AR; FLJ99960;
Gene ID
MIM
UniProt ID
P13945
Chromosome Location
8p12
Pathway
Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endocytosis, organism-specific biosystem;
Function
G-protein coupled receptor activity; beta-3 adrenergic receptor binding; beta-adrenergic receptor activity; beta3-adrenergic receptor activity; epinephrine binding; contributes_to norepinephrine binding; protein binding; protein homodimerization activity; receptor activity; signal transducer activity;

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