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Human ADRB1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0609
Background
The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central nervous system actions. These activities are mediated by GPCRs belonging to two subfamilies, the alpha- and beta-adrenergic receptors. The three members of the beta-adrenergic receptor family, beta1, beta2 and beta3, couple to Gs to increase cAMP upon activation. In the heart, the beta1 receptor constitutes 70-80% of the beta-adrenergic receptors. Activation of cardiac beta-adrenergic receptors, acutely increases heart rate, cardiac output, and cardiac automaticity, and chronically increases cardiac myocyte apoptosis. In failing hearts, the beta1 subtype is downregulated and desenstitized, probably as a result of increased catecholamine levels. As a result, beta-adrenergic receptor antagonists (beta blockers) are effective in the treatment of congestive heart failure and arrhythmia.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
ADRB1
Synonyms
ADRB1; adrenergic, beta-1-, receptor; ADRB1R; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; RHR; B1AR; BETA1AR;
Gene ID
UniProt ID
P08588
Chromosome Location
10q24-q26
Pathway
Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem;
Function
G-protein coupled receptor activity; PDZ domain binding; alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; beta1-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; norepinephrine binding; protein binding; protein heterodimerization activity; receptor activity; signal transducer activity;

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