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Human ADRA2C Stable Cell Line-CHO-K1/Gα15

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Cat.No.
CSC-RG1648
Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
Host Cell
CHO-K1/Gα15
Ship
Dry Ice
Antigen Gene Information
Official Symbol
ADRA2C
Synonyms
ADRA2C; adrenergic, alpha-2C-, receptor; ADRA2L2, ADRA2RL2; alpha-2C adrenergic receptor; ADRARL2; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; alpha-2 adrenergic receptor subtype C4; ADRA2L2; ADRA2RL2; ALPHA2CAR;
GeneID
MIM
UniProt ID
P18825
Chromosome Location
4p16.3
Pathway
Adrenaline signalling through Alpha-2 adrenergic receptor, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; adrenergic receptor activity; alpha-2A adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; signal transducer activity;

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