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Human ADRA2C/Galpha15 Stable Cell Line-Chem-1

Cat.No.
CSC-RG0608
Abbr
Chem-1-HuADRA2C/Galpha15
Alias
ADRA2C,ADRA2L2,ADRA2RL2,ADRARL2,ADRA2L2,ADRA2RL2,ALPHA2CAR
Growth Properties
Adherent
Host Cell
Chem-1
Shipping
Dry ice
Species
Human
Background
The endogenous catecholamines epinephrine and norepinephrine have profound effects on smooth muscle activity, cardiac function, carbohydrate and fat metabolism, hormone secretion, neurotransmitter release, and central nervous system actions. These activities are mediated by GPCRs belonging to two subfamilies, the alpha- and beta-adrenoceptors. The alpha2 adrenergic receptor subfamily members, consisting of alpha2A, alpha2B, and alpha2C, couple primarily to Gi to inhibit cAMP production, and play an important role in regulation of cardiovascular and CNS function. Experiments with alpha2C-selective agonists and knock-out mice lacking alpha2C demonstrate that activation of alpha2C results in impaired motor behavior and altered memory.

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