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Human ADRA2B/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1242
Background
Adrenergic alpha2b receptor belongs to the group of nine adrenoceptors that mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline. While alpha2a receptor exerts a tonic sympathoinhibitory function, the alpha2b is responsible for the central hypertensive sympathoexcitatory response. Development of agents capable of selectively activating the alpha2a or blocking the alpha2b may further improve our capability to treat hypertension, ischemic heart disease and heart failure. The alpha2b receptor also contributes to the peripheral regulation of vascular tone.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
ADRA2B
Synonyms
ADRA2B; adrenergic, alpha-2B-, receptor; ADRA2L1, ADRA2RL1; alpha-2B adrenergic receptor; ADRARL1; alpha-2BAR; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; G-protein coupled receptor; adrenergic receptor alpha 2B; alpha-2B-adrenergic receptor; alpha-2-adrenergic receptor-like 1; ADRA2B adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2; ADRA2L1; ADRA2RL1; ALPHA2BAR;
Gene ID
MIM
UniProt ID
P18089
Chromosome Location
2q11.1
Pathway
Adrenaline signalling through Alpha-2 adrenergic receptor, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; adrenergic receptor activity; alpha2-adrenergic receptor activity; epinephrine binding; protein binding; receptor activity; signal transducer activity;

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