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Human ADRA1B-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0169
Background
Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (alpha1a, alpha1b, alpha1d, alpha2a, alpha2b, alpha2c, beta1, beta2, beta3). The alpha1B-adrenoceptor expresses in brain, heart, kidney, and artery of various mammalian species and mediate diverse effects on cardiac functions, muscle contractions and cell growth. The knockout mouse models lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, reproduction, and the rewarding response to drugs of abuse. In vitro and in vivo studies also indicate that the alpha1b gene can function as an oncogene inducing neoplastic transformation.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
ADRA1B
Synonyms
ADRA1B; adrenergic, alpha-1B-, receptor; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; ADRA1; ALPHA1BAR;
Gene ID
MIM
UniProt ID
P35368
Chromosome Location
5q33.3
Pathway
Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem;
Function
G-protein coupled receptor activity; adrenergic receptor activity; alpha1-adrenergic receptor activity; receptor activity; signal transducer activity;

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