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Human ADORA2A/Clytin Stable Cell Line-HEK293

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Cat.No.
CSC-RG0601
Background
Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G protein-coupled adenosine receptors, A1, A2A, A2B and A3, is responsible for these effects. A2A, which couples to Gs, is expressed in basal ganglia and immune cells. A2A reduces ischemia-induced inflammation; however, A2A antagonists protect from neurodegeneration during Parkinson"s disease. Caffeine, the most widely used psychoactive drug, is a nonselective adenosine receptor antagonist, but its psychomotor stimulant affect is attributed to A2A expressed on striatal projection neurons.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
ADORA2A
Synonyms
ADORA2A; adenosine A2a receptor; ADORA2; adenosine receptor A2a; RDC8; adenosine A2 receptor; adenosine receptor subtype A2a; hA2aR;
Gene ID
MIM
UniProt ID
P29274
Chromosome Location
22q11.23
Pathway
Activation of TRKA receptors, organism-specific biosystem; Adenosine P1 receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled adenosine receptor activity; enzyme binding; protein binding; receptor activity; signal transducer activity;

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