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lamtor3

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Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Background
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
Synonyms
MP1; MAPBP; MAPKSP1; MAP2K1IP1; Ragulator3; ragulator complex protein LAMTOR3; PRO0633; MEK partner 1; OTTHUMP00000161681; OTTHUMP00000219461; MEK binding partner 1; MEK-binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1 interacting protein 1; mitogen-activated protein kinase kinase 1-interacting protein 1; LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; mitogen-activ; zgc:110207; late endosomal/lysosomal adaptor and MAPK and MTOR

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