The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
KRT86; keratin 86; hHb6; Basic Hair Keratin K86; HB6; Hb-6; Hb1; MNX; KRTHB1; KRTHB6; keratin, type II cuticular Hb6; K86; keratin-86; hair keratin K2.11; type-II keratin Kb26; keratin, hair, basic, 6; hard keratin, type II, 6; type II hair keratin Hb6; keratin, hair, basic, 6 (monilethrix).