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klrc3

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Official Full Name
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) killer cell lectin-like receptor subfamily C, member 2 DNA.
Background
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
KLRC3; killer cell lectin-like receptor subfamily C, member 3; NKG2-E type II integral membrane protein; NKG2 E; Killer cell lectin like receptor subfamily C member 3; KLRC 3; NK cell receptor E; NKG2 E activating NK receptor; NKG2 E type II integral membrane protein; NKG2-E-activating NK receptor; NKG2E activating NK receptor; NKG2E; NKG2E type II integral membrane protein; NKG2E_HUMAN; OTTHUMP00000235359; OTTHUMP00000235362; NKG2-E; LOC709790; KLRC2; NKG2C

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