Official Full Name
killer cell lectin-like receptor subfamily C, member 2
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.
KLRC2; killer cell lectin-like receptor subfamily C, member 2; NKG2-C type II integral membrane protein; CD159c; NKG2 C; NK cell receptor C; NKG2-C-activating NK receptor; CD159 antigen-like family member C; NKG2C; NKG2-C; MGC138244