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klra1

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Official Full Name
killer cell lectin-like receptor, subfamily A, member2
Background
Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Ddand H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2.
Synonyms
KLRA1; killer cell lectin-like receptor, subfamily A, member 1; T-cell surface glycoprotein YE1/48; ly-49a; lymphocyte antigen 49a; t lymphocyte antigen A1; class I MHC receptor KLRA22; natural killer cell receptor Ly49A; novel killer cell lectin-like receptor subfamily A protein; A1; Ly49a; Ly49v; Klra22; Ly49oCH29-493D4.3; Klra1; killer cell lectin-like receptor, subfamily A, member2

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