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klc1

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Official Full Name
kinesin light chain 1
Background
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various;cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains;bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy;chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in;binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as;adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the;kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms;with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or;biological validity of most of these variants have not been determined.
Synonyms
KLC1; kinesin light chain 1; Kinesin 2 60/70kDa; Kinesin2; KLC 1; KLC; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245; kinesin 2; kinesin 2 , kinesin 2 60/70kDa , KNS2; hKLC1B; hKLC1G; hKLC1J; hKLC1N; hKLC1P; hKLC1R; hKLC1S; medulloblastoma antigen MU-MB-2.50; KLC, KNS2, KNS2A

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