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kiaa0415

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Official Full Name
KIAA0415
Background
This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862).
Synonyms
KIAA0415; protein KIAA0415; SPG48; Hypothetical protein LOC9907; Uncharacterized protein KIAA0415

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