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kalrn

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Official Full Name
kalirin, RhoGEF kinase
Background
Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms
KALRN; kalirin, RhoGEF kinase; HAPIP, huntingtin associated protein interacting protein (duo); kalirin; ARHGEF24; DUET; duo; Hs.8004; serine/threonine kinase with Dbl and pleckstrin homology domains; TRAD; huntingtin-associated protein interacti

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