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jag1

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Official Full Name
jagged 1
Background
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Synonyms
Jagged1; JAG1; AGS; AHD; AWS; CD339; HJ1; JAGL1; jagged 1; AGS, Alagille syndrome , JAGL1; protein jagged-1; MGC104644

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