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itgb3bp

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Official Full Name
integrin beta 3 binding protein (beta3-endonexin)
Background
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Synonyms
ITGB3BP; integrin beta 3 binding protein (beta3-endonexin); centromere protein R; CENPR; HSU37139; NRIF3; TAP20; Beta3 endonexin; CENP R; Integrin beta 3 binding protein; NRIF 3; Nuclear receptor interacting factor 3; TAP 20; beta 3 endonexin; beta-3-endonexin; OTTHUMP00000015392; OTTHUMP00000015409; OTTHUMP00000015410; integrin beta-3-binding protein; nuclear receptor-interacting factor 3; CENP-R; beta3-endonexin

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