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irx5

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Official Full Name
iroquois homeobox 5
Background
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
IRX5; iroquois homeobox 5; iroquois-class homeodomain protein IRX-5; IRX 2a; Homeodomain protein IRX-2A; Homeodomain Protein IRXB2; Iroquois Homeobox Protein 5; IRX2A; IRX5_HUMAN; IRXB2; OTTHUMP00000164259; OTTHUMP00000164260; IRX-2a

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