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irak3

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Official Full Name
interleukin-1 receptor-associated kinase 3
Background
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Synonyms
IRAK3; interleukin-1 receptor-associated kinase 3; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK M; FLJ13601

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