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insig1

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Official Full Name
insulin induced gene 1
Background
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms
INSIG1; insulin induced gene 1; insulin-induced gene 1 protein; CL 6; INSIG 1 membrane protein; MGC1405; CL6; INSI1_HUMAN; INSIG 1; INSIG-1; INSIG1 membrane protein; Insulin induced gene 1 protein; INSIG-1 membrane protein; CL-6; fb55a03; fi35b10; zgc:55439; wu:fb55a03; wu:fi35b10

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