Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


  Order Info:   order info
Products
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

ikbkap

Bookmark and Share
Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Background
IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKK?, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.
Synonyms
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425; elongator complex protein 1; p150; OTTHUMP00000021869; IKK complex-associated protein; ikappaB kinase complex-associated protein

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2017 Creative Biogene. All Rights Reserved.
-->