This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
IFT122; intraflagellar transport 122 homolog (Chlamydomonas); WD repeat domain 10 , WDR10; intraflagellar transport protein 122 homolog; SPG; WDR10p; WDR140; CED; WD repeat domain 10; WDR10; WD repeat-containing protein 10; WD repeat-containing protein 140; zgc:77217