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idi1

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Official Full Name
isopentenyl-diphosphate delta isomerase 1
Background
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol.It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Synonyms
IDI1; isopentenyl-diphosphate delta isomerase 1; isopentenyl diphosphate delta isomerase; isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase; IDI1_HUMAN; IPP isomerase 1; IPPI1; Isopentenyl diphosphate Delta isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; Isopentenyl pyrophosphate isomerase 1; OTTHUMP00000018949; OTTHUMP00000018951; IPP1; zgc:114138

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