Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong;to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five;isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the;mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other;predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated;rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha;subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one;isozyme of NAD(+)-dependent isocitrate dehydrogenase.
IDH3A; isocitrate dehydrogenase 3 (NAD+) alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; H IDH alpha; isocitrate dehydrogenase (NAD+) alpha chain; isocitrate dehydrogenase [NAD] subunit alpha; mitochondrial; isocitric dehydrogenase; NAD(H) specific isocitrate dehydrogenase alpha subunit; NAD+ specific ICDH; EC 220.127.116.11; HIDH alpha; IDH3A_HUMAN; Isocitrate dehydrogenase (NAD+) alpha chain precursor; Isocitrate dehydrogenase [NAD] subunit alpha mitochondrial; Isocitrate dehydrogenase; Isocitric dehydrogenase subunit alpha; NAD; NAD(+)-specific ICDH subunit alpha; NAD(H) specific isocitrate dehydrogenase alpha subunit precursor; NADsubunit alpha mitochondrial precursor; OTTHUMP00000184906; H-IDH alpha; NAD+-specific ICDH; NAD(H)-specific isocitrate dehydrogenase alpha subunit; zgc:56380; zgc:85631