The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
HTR3D; 5-hydroxytryptamine (serotonin) receptor 3 family member D; 5-hydroxytryptamine receptor 3D; 5 hydroxytryptamine receptor 3D; 5-hydroxytryptamine receptor 3 subunit D; 5HT3D; MGC119636; MGC119637; Serotonin 5-HT-3D receptor; Serotonin receptor 3D; OTTHUMP00000210831; OTTHUMP00000210832; OTTHUMP00000210833; OTTHUMP00000225094; 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic; 5 hydroxytryptamine (serotonin) receptor 3 family member D