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hlf

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Official Full Name
hepatic leukemia factor
Background
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription;factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds;sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene;with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript;variants have been described, but their biological validity has not been determined.
Synonyms
HLF; hepatic leukemia factor; MGC33822

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