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hira

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Official Full Name
histone cell cycle regulator
Background
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Synonyms
HIRA; histone cell cycle regulator; TUP1; DGCR1; TUPLE1; protein HIRA; DiGeorge critical region gene 1; TUP1-like enhancer of split protein 1; HIR histone cell cycle regulation defective homolog A; cHIRA

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