This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
HEY1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; BHLHb31; CHF 2; CHF2; HERP2; HESR 1; HESR1; HRT 1; Basic helix loop helix protein OAF1; Cardiovascular helix loop helix factor 2; Cardiovascular helix loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split related protein 1; Hairy and enhancer of split-related protein 1; Hairy enhancer-of-split related with YRPW motif protein 1; Hairy related transcription factor 1; Hairy-related transcription factor 1; Hairy/enhancer of split related with YRPW motif 1; HERP 2; HES related repressor protein 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HEY 1; HEY1_HUMAN; hHRT1; HRT-1; HRT1; MGC1274; OAF 1; OAF1; basic helix-loop-helix protein OAF1; class B basic; CHF2, OAF1, HERP2, HESR1, HRT-1, BHLHb31; hes-related family bHLH transcription factor with YRPW motif 1; id:ibd1292; zgc:110572; Herp1; basic helix-loop-helix transcription factor