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hdac8

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Official Full Name
histone deacetylase 8
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms
HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; Wilson-Turner syndrome (mental retardation, X-linked, syndromic-6, with gynecomastia and obesity); HDACL1, histone deacetylase like 1; zgc:66196; wu:fd19a02

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