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h2afy2

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Official Full Name
H2A histone family, member Y2
Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms
H2AFY2; H2A histone family, member Y2; macroH2A2; core histone macro-H2A.2; mH2A2; histone macroH2A2; core histone macroH2A2.2; RP11-367H5.3, macroH2A2, H2AFY2; im:6898017; wu:fa14g05; zgc:114051; H2A histone family, member Y-like; H2A2

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