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h2afy

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Official Full Name
H2A histone family, member Y
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
H2AFY; H2A histone family, member Y; core histone macro-H2A.1; macroH2A1.2; Core histone macro h2a.1; H2A histone family member Y; H2A.y; H2A/y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; Medulloblastoma antigen MU MB 50.205; mH2a; mH2A1; histone H2A.y; OTTHUMP00000159413; OTTHUMP00000223174; OTTHUMP00000223175; OTTHUMP00000223176; medulloblastoma antigen MU-MB-50.205; H2AFJ; H2AF12M; MACROH2A1.1; H2A.y, H2A/y, H2AFJ, mH2A1, H2AF12M, MACROH2A1.1, macroH2A1.2; wu:fa93c12; zgc:136891; H2A1; fa93c12

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