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h2-d1

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Official Full Name
histocompatibility 2, D region locus 1
Background
The "classical" MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.
Synonyms
H2-D1; histocompatibility 2, D region locus 1; H-2 class I histocompatibility antigen, L-D alpha chain; Q5k protein; MHC class I H-2Dp; MHC H2-D-q alpha-chain; MHC class I H2 antigen; H-2D cell surface glycoprotein; H2-DC1-beta transplantation antigen pro

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